I gave it a try on macOS and it worked.
I had to fumble a bit to get it to install.
I used a wine wrapper for the gog installer to work but as soon as the game was installed, I moved the files somewhere more appropriate, removed wine wrapper and its files and added the game to scummvm.
You can probably skip wine and use a different method to install this (use a win VM, bootcamp, a separate computer). Once it is installed you just need the Phantasmagoria folder under C:\GOG Games\. You can move it anywhere as long as your mac can reach this folder. Just add the Phantasmagoria folder to scummvm.
I don't know if the default options work (because I always browse the settings before playing).
The only settings I changed are MIDI and MT-32 which I have set to Apple DLS Software Synthesizer.
Both background music and audio work for me.