Does anyone know if this is known problem, or a fix is on the way? I can't leave my keep now without the game crashing. Happened straight after the latest hotfix, and now it's unplayable

I had some similar problem before. I did several things to solve it:

delete the game. take the saves somewhere else. delete the owlcat games file in appdata.
restart the computer.
install the game again. (i did it via galaxy, as it gives the best results)
put some save file from before the time, when the incident happend, in the owl games save file.

start the game again and hope for the best.