I believe it is Chapter 3, Level 4 when you take on the boss at The Ruins (the guy with the hammer). For some strange reason or another, I get close to killing him and then the game crashes. I haven't experienced anything like this up this point. It always happens at the exact same moment his health reaches a certain point.

Any help or suggestions would be much appreciated.
Well, nevermind with all that. I lowered the resolution just for this specific boss and it played out just fine. As soon as I beat him I put the resolution back to what I had it and I haven't experienced the problem since.