Allom: You are the MAN!!! Thank you! This works perfectly! Only problem is that the game itself doesn't have a setting to change mouse scroll speed. Ah well. Thanks again!

xixas: I'm glad I could help =)

You should probably know that since OS X El Capitan (10.11) was released, Wineskin 2.6.0 no longer works. Wineskin 2.6.1 fixes the problem, but I've only tested it with newer versions of the Wine engine so far (WS9Wine1.7.29+). They'll likely work fine for Nox, but again, I haven't tried it yet. I'll add a note to the post.

Allom: This is way off topic, but is there a way to figure out how to run Return to Krondor? The only wineskin I could find has major problems with it, and I don't know enough about wineskin for what wine tricks and stuff should be used.

xixas: Excerpt from Q: Can't get past the character creation screen. Help please!

This addresses an issue for Nox (version 1.0.0.10) on OS X where the game hangs on the character creation screen when the Accept button is clicked.

How to create a functional Nox via Wineskin for Mac OS X (tested on Yosemite 10.10):
(Update: See OS X El Capitan 10.11 Update at End of Post)

(1) Download the Windows version of Nox from GOG (currently version 2.0.0.20)
(2) Download and install Wineskin Winery 2.6.0
(3) Run Wineskin Winery and install the engine WS9Wine1.4.1
(4) Create a New Blank Wrapper named Nox.app
(5) In Finder, Show Package Contents (via Ctrl+Click menu) of Nox.app
(6) Run the contained Wineskin.app
(7) Under the Advanced section, use Tools > Winetricks to:
* Install the gdiplus DLL
* Set ddr=gdi
(8) Click Install Software button (at the bottom of the Advanced window) and select the Windows Nox installer exe file you downloaded earlier.
(9) Complete the installation, agreeing to the EULA and using the installer defaults—if you can't see the buttons, just use the Enter key to progress through each screen.
(10) Set the runnable Windows EXE option to use NOX.EXE
(11) Click Set Screen Options and change the following (click Done when finished):
* Override Wine control of Screen Settings? - Override
* Override Settings - Fullscreen
(12) Click Test Run to see if everything worked correctly—if so, you're done—if not, review above.

As an aside, you can convert the gfw_high.ico icon file in the nested Nox game directory to a Mac compatible format (ICNS) using something like iConvertIcons (has an online web-based converter) and set the resulting gfw_high.icns file as the Wineskin icon in the Advanced > Configuration tab.

Additional Note (OpenGL vs. GDI):
Setting ddr=gdi isn't strictly required, and it will likely make the video scenes choppy and difficult to watch. Instead, you can set ddr=opengl, which will make the videos play more smoothly, but may also add some vsync issues / screen tearing during gameplay at lower resolutions. If you prefer to use ddr=opengl, I recommend playing at 1024x768 instead of 640x480.

Update (2015.10.27) - OS X El Capitan (10.11): Since OS X El Capitan (10.11) was released, Wineskin 2.6.0 no longer works. Wineskin 2.6.1 fixes the problem, but I've only tested it with newer versions of the Wine engine so far (WS9Wine1.7.29+). Should be fine, but I haven't play tested it. Your mileage may vary.