Ad_Hoc: Hello all, I've been playing this game for more than a year, yet in the last month I've encountered a pervasive freezing problem that forces me to reset my PC. I'm using Windows 7, and have set nwn.exe to compatibility mode among other things. I've tried reinstalling to no avail. I'm at my wit's end, and I don't know why it's decided to start acting up all of a sudden.
Most likely cause would be graphics drivers - newer versions have a growing tendency to "break" older games.
Although this may seem contradictory advice, first check whether your system has the latest drivers for your graphics card (check with the manufacturer's website, don't rely on Windows Update) and if not, try an update.
If that doesn't help, try an older driver version (ideally, what you were running when you first installed NWN), but this may affect performance for newer games.
Also, make sure that you have software installed to monitor GPU temperatures (MSI Afterburner being a good example for AMD/Nvidia GPUs). It's unlikely that NWN1 could be causing temperature spikes, but a persistent lockup with no other factor than time played does hint at a temperature issue.