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I bought NWN 2 Complete.

I launch the game and it appears to start in 1024 x 768. I change the resolution to 1920 x 1080 and get a black screen where I can only see the mouse cursor. I can't click anything or so anything. I kill the game and relaunch it and it returns to 1024 x 768.

So I Google this and apparently this is just a known issue in the final build of the game that you can't change the resolution while in fullscreen mode like this.

You have to switch it to windowed mode, then change the resolution and then change it back to fullscreen.

GOG should patch in an .ini file that sets the resolution since people can't set it themselves in fullscreen.
You'll have to go into the the NWN2 files (PC > GalaxyClient > Games > NWN2 Complete > nwn2.ini) and manually change the resoultion. Scroll down to Display Options and change Width=1920 and Height=1080.