This is almost my favourite build, except that fragile can be really annoying even in late game, so I usually go for the metabolism flaw and drop medic to avoid that. But builds like that are great for how many options you get in story encounters, so I really like them.
Tips for early game/freezing:
1) Make lockpicks as soon as you find enough small parts, they offer a pretty decent and very safe scavenging advantage, even in locations that aren't locked. Lit torches are also great as scavenging boosts in early game (when you don't have a lighter yet) but they work like beacons for every deadly thing around, so they're more of a risk/reward decision.
2) If you're really hypothermic, don't waste time scavenging locations that won't drop clothes (like offices). Go for appartments preferably, and always go for shacks in the wood, they offer some of the best loot in the game.
3) You will never freeze if you go to the trouble of always dropping your sleeping bag in the ground at the end of every turn. Since the sleeping bag encounter always appears when your temprature is low enough, you basically never have to die from hypothermia if you carry it around. It is the dev's safety valve against the cold, and he made it purposefully annoying (so as not to be too OP), but it can be really important with weak builds.
