Is anyone able to get this working in full-screen? I don't have high expectations (if I have to play 640x480 that's fine), but right now it's running in windowed mode with a huge border of black all around it.
I am running Windows 7 32-bit and I unchecked the compatibility option.
Thanks!

That's how Myst always was if I recall.

Yeah the game is just built that way. If there is a mod to force fullscreen on it I don't know about it.

So it _has_ to be run in Windowed mode? I remember I had this game way back in the day when I got my Mac Performa 630CD.... even though it was slow as molasses it was still in full screen. Never played the PC version until now.

Uh, I don't know what's going on with you guys, but the game has ALWAYS been fullscreen for me, on Win3.X, 98, and XP, original or masterpiece, CD or DVD. Given the focus on immersion, it's certainly INTENDED to be fullscreen.
...Um, unless you mean the black border around the image. Windowed mode means that the game is running in an OS window floating over the desktop - taskbar and all that still visible. It shouldn't be doing THAT. But yes, even in fullscreen mode the image has always had a sizable black border. If you are seeing the "viewport" area centered in the screen with an inch or so border around it, a couple inventory slots on the bottom and an auto-hiding menu at the top, but no taskbar or other remnants of the Windows interface, then you are seeing it correctly. In 640x480. The width of the black frame doesn't change. Either you are in 640x480, or you are in true windowed mode with the desktop interface visible. In other words, the actual image area is SMALLER than 640x480, and black space is used to fill in the rest. (rendering took a lot longer back then - they conserved all the pixels they could.)
The border shrinks a little in Riven, and becomes only a narrow letterboxing in Myst III and IV.