Steps for reproduction:

1) Install game
2) Configure Graphics to AMD FSR 1.0, Performance preset
3) Start a new game
4) Click the Myst book
5) Open and close the door to the hologram projector room
6) Wander farther down the dock
7) Notice the "Press Escape to open the menu" notice
8) Press Escape to open the menu
9) Open Graphics settings again
10) Change the AMD FSR 1.0 preset to Balanced
11) Click the Apply button
12) Note that both monitors have locked up, and nothing responds except for the mouse cursor

Running 1.5.3 on an M1 Mac mini, with two monitors (3840x2160@60Hz, 1920x1080@60Hz), 16GB RAM, 256GB storage, external NVMe SSD on Thunderbolt.

E: I have seen that I should forward this to Cyan support. I have emailed them now, with slightly more details. I have asked them if there is any way for me to collect any useful logs for them.

E2: A completely different Unreal Engine 4.26 title similarly locked up within 20 minutes of gameplay, while also running a Skype video call. I can't blame Unreal Engine for this. It must be either Monterey, or faulty hardware.

Feedback posted to Apple, FB9704932 for reference.