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After updating the game to 1.82, it gets stuck on the first loading screen and the log mentions the following:

PlatformNotSupportedException: Operation is not supported on this platform.
at Newtonsoft.Json.Utilities.DynamicReflectionDelegateFactory.CreateDynamicMethod (System.String name, System.Type returnType, System.Type[] parameterTypes, System.Type owner) [0x00018] in <97722d3abc9f4cf69f9e21e6770081b3>:0
at Newtonsoft.Json.Utilities.DynamicReflectionDelegateFactory.CreateDefaultConstructor[T] (System.Type type) [0x00010] in <97722d3abc9f4cf69f9e21e6770081b3>:0
at Newtonsoft.Json.Serialization.DefaultContractResolver.GetDefaultCreator (System.Type createdType) [0x00005] in <97722d3abc9f4cf69f9e21e6770081b3>:0
...

This can be worked around by downloading "Json130r1.zip" from https://github.com/JamesNK/Newtonsoft.Json/releases/tag/13.0.1 and then extracting "Bin/netstandard2.0/Newtonsoft.Json.dll" to "game/mutazione_Data/Managed" in the game installation directory, overwriting the version of the library included in the game.

As a warning: this workaround will not be able to load any existing save data from previous versions and it will overwrite existing saves if you start a new game with this. Newly created saves with this workaround will still work as expected though. However I'm not sure if saves created with this workaround will keep working if the developer publishes another update.