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E - play (release the mice) / toggle fast-forward on and off
Enter -pick up brick / place brick
Backspace - Undo
A & D - cycle through available bricks
Space - rotate bricks
Shift - use a bomb (Right-click also uses a bomb.)
Left & Right Arrows - scroll the screen (Does not work when the mouse cursor is low on the screen.)

The shortcuts are only revealed sporadically on levels throughout the early game. They are not listed in the game options, on the developer's website, or anywhere on the internet I could find. (Yay.) If you find one I've missed, please let me know and I'll update the list.
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grimwerk: If you find one I've missed, please let me know and I'll update the list.
F to pause the game.