Is there any way to increase the size of the game interface without playing at a tiny resolution for ants?

Help would be appreciated, cheers.

To get a larger interface you need to choose a lower ingame resolution then either

1: Tell your GPU drivers to scale the lower resolution to fullscreen (all GPU drivers have this option). This will be blurry, but otherwise look perfect.

2: Run nGlide configurator (I'm assuming the GoG version of this game ships with nGlide, I have the retail copy) and set "Screen resolution" to "By desktop" and "Aspect ratio" to "Preserve original". For this you need to make sure "Glide" is set as the driver in the game options. This will look much sharper, but might introduce minor graphic glitches.