When I try to launch MDK2, all I get is a black screen (or window, if I try that mode). I've tried compatibility mode, various other settings, using only one core, giving it real-time and low CPU priority, etc. Nothing works.
My specs, if it helps, are:
HD4870 512MB
2GB DDR2 RAM
Athlon 64 X2 6000 ~3ghz
Vista Ultimate 32Bit

I've managed to get the game running in Ubuntu, through Wine, but I would prefer to have it in Vista, as I use it more often.
EDIT:
I managed to get it running on my work laptop, with Vista Business. I reckon there is a application or something that's interfering with it. so I guess I'll try a clean boot.

Managed to get it working in Vista. By reformatting and reinstalling.

Now I can't recreate the error, so I've got no idea of what process it might have been...
And since I can't set my schizophrenic self responses as solutions, I'll just mark your post.

Great!
(this way it won't look if there are a lot of unsolved problems with MDK)