I haven't encountered any major issues - just some small annoyances.

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I. Locks up on Menu's Exit To Desktop, requiring an Alt+Tab+Delete or a reboot.
A. Press the Windows Key or Alt Tab, right click on Mary Skelter and close it.

I. Dungeon icons disappearing / lingering.
A. Reloading the game seems to work. Simply use Alice's Rabbit Hole to Save. Then, go into the Menu > Settings and Load that Save.

I. Choppy enemy animations.
A. Open the Mary Skelter Config file and switch UnlockAnimations=0 to UnlockAnimations=1. This may cause certain enemy animations to go wack but... at least the ghosts get tossed back smoothly!

I. Fullscreen on secondary monitor?
A. Utilize Settings.Ini ( or MarySkelter.Config ) and switch DisplayMode=2 to: DisplayMode=1
( Special thanks to MaverickRonin for providing the issue and a solution! )
( TYVM MaverickRonin )

I. Playing on a decent laptop - but the game is slow!
A.Open the Mary Skelter Config file and switch AdapterNumber=0 to AdapterNumber=1.
( TYVM Feeder_178 )

I. I have multiple controllers plugged in but the game won't recognize input.
A. Go into the game's Settings menu from the Main Menu. On the Controller option, switch the numbering until the controller you want works.
( TYVM Fender_178 - twice )

Mine was rendering full screen on one of my secondary portrait oriented monitors.

Changing DisplayMode=2 to DisplayMode=1 in the settings.ini moved it to my primary monitor.

Oh, I've had that happen with other games in the past. Totally adding that to the list! Thanks.

Also for laptop users who have 2 GPUs the Igpu (Intel) and a Separate discrete GPU (Nvidia or AMD) Make sure you set The Adapter number from 0 to 1 to use dedicated GPU (Nvidia) Which will help performance as well.

Thanks you!

My laptop has two moderately powerful GPUs so... unless it's breathing, I never notice a performance impact. Will try this out!!

Np,
Also for those who have two controllers plugged in and the game doesn't use your xbox controller after launching it go into the game settings under Controller number and switch it to two and it should fix it.

I've been tinkering with the config file, and I'd like to correct some of the information you guys posted here based on what I found out. DisplayMode determines whether the game runs in Windowed (0), Borderless fullscreen (1) or Fullscreen (2) mode, and has nothing to do with the monitor the game uses. AdapterNumber lets you choose the monitor, not the GPU. 0 is the main monitor, 1 is the secondary one, etc.
You should use your discrete GPU's control panel to force the game to use it.