I'm having a problem trying to work Defiance with Xpadder, I made a profile of all the keys to my wireless Xbox 360 controller and when I start the game, nothing on the controller works yet it works fine with Blood Omen 2. Even stranger is I can't configure the controller keys if I mapped them in the game itself.

I'm using the 2012.05.01 version which should be the latest version I believe.