I am playing soul reaver and I am using a 360 wired controller which I setup with xpadder but I can only look left and right not up and down. How do I look up and down?

SR1 and SR2 actually don't allow you to look up and down unless you use "look around" mode. As I mentioned yesterday, for X360 controller the right stick X axis is bound to triggers. I'm not sure whether there is software to bind axes properly.

With the other 2 games can I use the Mouse to look around and WSAD to move?

You can use WASD in SR2, but it has it's own problems. Forward does not work in combat and look around modes (it does work only if the arrow keys are used) and in combat mouse controls movement instead of camera. But while walking you can look around with mouse without restrictions. Interestingly, I didn't find anyone else reporting these bugs so perhaps in not present on all PC's.

BO2 works fine with WASD, but the game has no strafing outside of combat, so it can take some time to get used to it.

Defiance only has a fixed camera that only can be tilted and not moved. Keyboard works but gamepad is heavily recommended. With keyboard you will be zigzaging instead of running in straight lines through most of the game.

Thanks.

I notice a major sound issue with SR1 where sound and voice cut out a lot please tell me that it is only with SR1 and no the others. It can be a little hard to understand what is going on when audio cuts as they are talking.

Yes, only SR1 has sound problems. The problems appeared with WinXP and are present on every system since then.

Well I as you know now from my other post I am on SR2 and I got my gamepad to work really well to my liking. I use the second stick (Right) for camera and works great and the first stick (left) to move works great. Right trigger is Autoface (lock on) and right trigger is Block, A is jump, X is action, Y is soul eating, B is nothing, Right bumper is heavy attack, Left bumper is crouch.

For Blood omen 2 and defiance is there a gamepad support so I don't have to use a program to do it?

BO2 and Defiance have the same controller support as SR2, which means it supports DirectInput but may require some workarounds for Xinput (X360 controller).