[UPDATE]
Okay not the only one thought I was doing something incorrectly.

https://steamcommunity.com/app/1733170/discussions/0/4699035455825415741/
[UPDATE]

I have gotten all 10 vessels and have them all in the machine above the bed chamber but the "magic door" remains sealed.

I looked up a walkthrough and watched a youtube vid but I don't see anything else they have done that I have not.

I have reloaded game save and switched PC I was playing on to no difference.

Making manual saves and even backups of it at differ slots is mandatory thing. Never ever relate only on auto/continue/quick saving. And for games - such games exist - that wont allow manual saving if auto save feature turn on (dont provide save slots/names to chose having only one per profile) - turn autosaves off.
Its a bad design and not. Autosaves saving fails is made for continue feature and fully legit. Bad design it is only if that affect manual saving.


Also quick load and restart is not real reloading of level assets for most games. In case of troubleshoot the issue by level reloading you need full reload with Loading... screen.

If some quest related items already half-functionint placed after quick save -> qucik load it is a bug, indeed. And at same time it is come after quick reoading which come after overusing (savesscumming cheating as its also sometimes called) quick save-load function and kinda normal that sometimes quest scripts affected.

So to avoid gameplay (RTS genre and one-save only games like Need for Speed games) and technical issues try to manual saves before supposedly next level/map loading. Sometimes for strange no reason make some (old only?) games work faster(*better): start the game, start the gameplay, exit to menu or some kind of FULL reload by alternate save/changing the level, reload needed save file or needed level.
Level/location reloading is a key.