Have been playing Iwd2 over the last few weeks. Almost finished the Prologue and suddenly cannot enter/exit buildings after loading a save game. Anyone seen this kind of behaviour before? All my save games are doing this now!

There is a quirk (bug?) in the Infinity Engine whereby interaction with objects/people cannot be completed, after playing for a while. The odd thing, in relation to your problem, is that loading a save game cures it. Having said that, and considering this is happening with all of your save games, my instinct would be to suspect a driver issue, so try a simple reboot of your computer.

Tested with rebooting and it made no difference. The problem comes up in all save games made with GemRB installations. Seems to be a compatibility issue with the vanilla game.

Replayed the Prologue at an easier setting to get it done quickly, now cranked back up to maximum again :)

I was hoping it was something else. Used wide-screen mod to move between vanilla and gemrb installs, and thought I would be safe..