So yeah, if I try to use my desktop's native resolution when playing, the mouse pointer is off by almost an inch of whatever I try to select in the game screen. The only workaround I've found is to lower my desktop's resolution to 800x600 (which seems to be the game's native resolution, btw) and only then the pointer is accurate. I don't mind to change the resolution of my notebook that much, but I'm pretty sure that people with, em, larger screens might find themselves getting a little bit too fucking pissed off by this... any suggestions?

Okay, I'm running this game on windows 10 and was dealing with the same problem. Here's how I fixed it:
1. Go to the directory where GoG , or Galaxy installs your games.
2. Go to the Huniepop folder.
3. Right click the file that your computer labels as being a shortcut for Huniepop.
4. Set "run as administrator"
5. Run in compatability mode for Windows 7.
6. Adjust the desktop resolution if you need to.