Is there a way to set or force the in-game langage setting ?

The game as detected my system is in French and forced the game in french including keyboard bindings that are incompatible with my keyboard layout. I want to put the game back in English.

You can change your language from the menu once the prologue is over. I don't know if this affects your keyboard layout though.

If your keyboard mapping is still broken after changing your language, delete controls.dat (it's supposed to be in %USERPROFILE%\Documents\HotlineMiami2\).