BastianWeaver: Is there a way to defend yourself against Skatter's firebreathing attack? I've tried Null runes, but they didn't seem to work. Whenever they used this attack, it hit me automatically. Cloister runes work, of course, but Skatters tend to travel in flocks, which is sometimes a problem.

cbingham: The Frigida runestone makes you immune to their fire breath.

An even better solution is to sneak up behind them and kill them in one hit. You can do that routinely if you have the stealetto, good stats, and you sneak up behind them not in front of them.