I've been having the game crash on mac during combat when I use the weapon's powers, such as the Huge Hammer or Thunderstrike.

Usually it seems the game is having trouble with the power being registered at the same time as another action is taking place like another power or a enemy appearing or an enemy doing it's signature move. Iv'e had the game crash at the final fight against the three scales card and also multiple times versus the golems and the queen of rats in the blacksmith's cave encounter.

I had to force quit every time which put me back before the encounter, which in the case of the boss fight is tedious, and especially aggravating for the blacksmith encounter since you need the great succes card every time you restart.

I usally had a superior shield, a weapon with a power, a power, and a mask with an ability in combat such as the helm of reflection, but it has also happened with simply a weapon with a power and the standard gear in late game.

Ditto. I'm playing in Mavericks, with a Radeon 6750M.

Looks pretty fixed so far. One new regression - "Simple" graphics has a black sooty mess dancing all over skin textures, especially the dealer's arms. Problem is independent of the 4 graphics toggles, and doesn't manifest on any other quality setting (even FANTASTIC 3FPS).