I have problems, I just bought the last expansion of the game and the buttons of the menu do not work even if I click on any option of the menu nothing happens and I can not play, nor change the language, nor change any parameter it is as if the game was blocked .

Try verifying the game files.

I have this same problem and I tried verifying game files. Still does not work.

Maybe change some mouse property, such as removing the echo of pointer (1st visibility option)

Turn off the ingame overlay. In GOG galaxy select more, then settings. in-game overlay is on the bottom.