The game runs great, except when performing a fully charged adrenaline attack as kabuto. Maybe 15-20% of the time the game will crash to desktop. It happens in multiplayer as well as single, I haven't tested to see if it happens when someone else as kabuto does the attack.
Machine specs,
Athlon x62 dual core +5200
2GB ram
Nvidia 8800GT
Windows XP 32-bit

I installed the GiantsHook patch and that seems to have cleared it up.

I have the exact same problem!
The GiantsHook patch you mention...Is this it?
http://www.giantswd.org/?file=31&search_name=hook+&search_author=neo&search_type=&search_db=&sort=Name&Submit=Search

Yup, that's the one I used.