The thing with Christine in FNV's Dead Money DLC is that the subs did all the work that the character couldn't (whether from lazy development or the engine not being up to subtle movements), the subs say she points to the door or gestures to her throat or makes a circle motion with her hands all whilst the character is standing there with her arms crossed.
Wishbone: I have had too many bad experiences with games where the sound mix is really horrible. This is especially bad in dramatic cutscenes, because here the music often swells suddenly, sometimes completely drowning out the words being spoken. Since this is also usually the time when games reveal key plot points, and that sort of cutscene can rarely be re-triggered, this means that without subtitles, I'm liable to miss key points.
Bloody, bloody annoying that. Thats the exact same reason I have subs on myself. When you turn the music down or even off they can still be drowned by local sound effects. Its particularly bad in things like Fallout 3/NV because the engine has that annoying habit of making tiny bits of battle debris bounce endlessly when inside another object making much of the dialogue drowned out by an incessant clunking noise