http://www.gamesradar.com/f/123-games-with-untapped-franchise-potential/a-2009043091222114037
I quite liked this little article...some bits already on GoG and some that seem like they'd fit in pretty well on the PC side of things. Some on here's I'd not heard of prior that get me to thinking too...

its too big!! ;-)
based off only the first page its a bit of a strange mix of very obvious (psychonauts, full throttle...) and more obscure...
Samurai western at least looks like its getting a new chance as Red Steel 2...

I wish they would make a Dragon Force and Guardian Heroes sequel. I still own them for the sega saturn ans they are two of my favourite games evar...