http://dfendreloaded.sourceforge.net/index.html
Any of you guys using this program? Is it good?

/\ As Arkose said. It's a great frontend, as long as you don't need to feel like l33t g33k

I use it, it makes it easy to have different dosbox setups for different games.

I had it for ages, but didn't use it much because the games didn't seem to run right. then I realised it was because the default hardware setup it uses for dosbox is very old and slow, and the games i'd been trying were all a bit newer. Selecting another profile made them run nice and smoothly.
I think that's the only real flaw, it doesn't explain a few things as clearly as it could.

It is quite good, but it has some serious game listing refresh problems if you want to have mor than two dozen games installed there. This is sadly a deal-breaker for me.

Well, i had to manually edit everything D-Fend found in the gamescan. [Slow fullscreen gaming, even on older titles, screen corruption due to wrong output mode.]
I operate much faster on my own in the DosBOX environment, ocasionally [once in a 12380492342317 times] changing the conf file. Way faster in my opinion.

I didn't know about this. Thanks for the heads up, now maybe I can get No Regret to work properly.