Yeah! I remember when Aeris died in Final Fantasy 7, I was like:
MEH!
That's the strongest negative gaming reaction I remember.
On the positive reactions though, many games have certainly made me burst out laugh. Monkey Island 2, Grim Fandango, Space Quest IV, 4D Sports: Driving (the tunny crashes) etc.
DubConqueror: In the opening mission of Call of Duty Black Ops you're send on a mission to assassinate Fidel Castro and shoot him in the forehead. Of course in every FPS you kill people, but shooting Fidel Castro feels so utterly wrong: it's not only the murder of a person, but the murder of an ideal as well. The following is less horrendous luckily (but I won't post spoilers).
Couldn't you shoot him in the dick instead? That would have felt less wrong.
That reminds me: the phosporous rocket attack order thingie in Spec Ops: The Line kinda put me off, but not so much because lots of virtual civilians died, but because the game tried to be more "clever" there than it really was. It was like the game was moralizing me for ordering the attack, when in reality the game didn't give me any other choice, other than stop playing the game. That was such a stupid moral gimmick that... something.