Never uninstalled since the day i bought them because they are my favourite sims and i keep playing them frequently:
☆ Grand Prix Legends (since ~2001)
☆ Nascar Racing 2003 Season (since ~2010)
☆ Richard Burns Rally (since ~2009)
☆ GTR 2 (since ~2007)
☆ Power & Glory 3 (since ~2008, v2.0)
☆ Falcon BMS (since ~2012, but also vanilla F4 before that)
☆ IL-2 Sturmovik (since 2001)
☆ Microsoft Flight Simulator 2004 (since ~2009)
☆ Kerbal Space Program (since 2016)
Aside from all the above sims, there are also some other permanent residents in my HDD:
Age of Empires II, StarCraft, Anno 1404, Alpha Centauri, Command & Conquer: Generals, Lord of the Rings: Battle in Middle Earth II, Crusader Kings II, Heroes of M&M III, Atlantic Fleet, Banished, Into the Breach, NEO Scavenger, Risk of Rain, Curious Expedition, Tales of Maj'Eyal, Papers Please, Eufloria, Battle for Wesnoth, Open TTD.
As for your games, i'd suggest you to keep Crusader Kings II because not only is it highly replayable, but there are also some great mods for it. Aside from this, i'd keep NWN (for the custom modules), Banished (a lot of replayability) and FTL (same as above).
Telika: - AvP (I'm sentimental)
I used to keep this installed for years after i've finished the campaigns, mainly because of the Skirmish mode -- i loved that mode back in the day.
misteryo: Elder Scrolls Games - It takes me well over a year to complete one.
I'd add the number of mods one can install, a time-consuming process that can be tedious to do it all over again should the need to replay them ever comes.