Hellblade: Senua's Sacrifice (2017)
A young Celtic warrior embarks on a journey to the Norse underworld in order to avenge her dead lover. The hero of the story, Senua, suffers from psychosis and the developers consulted with several psychiatry experts to represent it as accurately as possible, and even based the game's puzzles and visuals/sounds on the experiences told by people with the same illness. The depiction of a mental health issue is still taboo in our society, but Hellblade manages to turn it into an essential element of its story (Senua suffers the ignorance of her own society, not that different from ours, as much as the illness itself) and develops an incredible gaming experience.