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pkk234: Realistic damage and wounds in GTA maybe?
You get shot multiple times and you have to wait a really long amount of IRL time in-game in the hospital to 'recover'.
Or you break a leg and have to wear a cast, also for IRL long ass time.
Sounds like Robinson's Requiem.
An open world game where all the Quest markers are constantly on-screen.
Thought of another one:

Desert Bus, except:
* You have to pay, with real money, for fuel before setting out; if you don't get enough, the bus will stop midway through, and you will have to be towed back to the start (in real time).
* You have to pay, with real money, maintenance costs for the bus before you can start the return trip.
* If you get towed (by veering off the road, or by running out of gas), you have to pay real money to get the bus out of impound in order to try again.
* Randomly, the bus may break down, forcing you to again wait to be towed, pay the impound fee, and pay the maintenance costs before you can try again; this is especiallly likely near the destination.
(Remember, all these payments are in real money, so have your credit card ready while playing the game.)