dtgreene: The problem I have with comic books is that it's not clear in which order the text is meant to be read.
Many column formats have this same issue.
What comic books do you read? Usually it's very clear. There are several techniques to guide the reader.
Of course first of all you follow the panels from top left (manga from top right, japanese read from the right to the left).
Then you follow the bubbles following the closest one to the character, these can go over multiple panels if there is a conversation happening. They bubbles of two character can also be placed alternating, making the conversation look like this:
(characters)
| |
A |
| B
A |
| B
A |
| B
A
If there are more than two chars speaking the other bubbles usually follow the general direction of the conversation.
This creates some dynamic with also the option of one interrupting the other without needing another panel to display it.