I can't get gothic 3 to run, any hints? I have Windows 10 and I'm running on a Radeon graphics card

First, you'll need to provide some more info.
- Are you trying to start the game through Galaxy? Or did you install the offline installers and start the game through the start menu?
- What exactly happens when you try to start it? Nothing? Or do you get an error message?

Also: did you contact support about this? That should be the first. Those are the guys who can help you best, since it's their job to help. https://support.gog.com/hc/en-us/categories/201400969

What is the issue? It not running at all or does a specific error message come up?

Some advice:

Did you try checking the Gothic subforums here to see if someone solved the issue you are experiencing?

You could also send gog a support ticket via clicking support above, then game technical issues, then click contact us near the new page's bottom, then filling out the form that pops up and sending it to gog.

Regardless I hope you get this sorted out.This....also dammit ninja'd :D

The first thing I would suggest is that you make sure that you have DirectX 9 installed, as it is a common mistake to assume that it is included with later DX versions that come preinstalled with newer versions of Windows.