Did you reinstall the games, or just try to play them after a Windows 10 upgrade? Not sure if something might have happened there and uninstalling + installing the games again might be a good idea.
Lands of Lore is a DOS game (probably running in DOSBox, sorry I can't be arsed to check now), so certainly it should work. Sound stuttering might be possible to fix by editing the dosbox config file, e.g. the blocksize and/or prebiffer values under [mixer], or possibly changing the amount of CPU cycles for the game (Ctrl-F11 and Ctrl-F12?).
When I tried many GOG (Windows) games on Windows 10, most seemed to work fine. I had issues here and there like Carmageddon 2 installation failing (that should be now fixed by GOG, but I haven't tried the fixed version), Alien Shooter graphics flickering madly all the time, and Alone in the Dark The New Nightmare graphics being broken (everything is grey, as if textures are missing). Also I've heard Shogo and some others are also broken in Windows 10, as well as Windows 8.x.
For some issues there may be workarounds, some GOG is fixing or has fixed. But yeah, you might lose some backwards compatibility, at least compared to Windows 7.