dtgreene: Apparently, in Lightning Returns: Final Fantasy 13-3:
One of the superbosses can only succumb to a status ailment if you hit the boss twice with the status effect.
(Note: I haven't played the game; I only happened to read about this on a wiki the other day.)
In any case, I think this could actually be a good way of handling more severe status ailments in RPGs, particularly if the target is a boss.
(One could also make it take more successes to inflict the status again after each time the status effect works; this would be similar to the way some Etrian Odyssey games increase resistance to a status after each time it's afflicted.)
Actually this is an interesting angle to this conversation. It actually makes me realize how boss immunity is annoying given that status ailment immunity should actually be a rare thing. Outside if pokemon, i've found status ailments to be annoying because boss immunity is too damn common.
But closer to the topic is another angle: in Monster Hunter, the bosses (pretty much the only thing you really spend any length of time fighting) are usually only immune to things for [i]logical[i] reasons (like a poisonous creature having poison immunity). When an element sticks to the monster (takes multiple hits of something to actually trigger the ailment), it's resistance to that ailment increases. For example, first time you paralyze a monster might take 10 arrows with the paralysis coating, and it'll be paralyzed for about 5-10 seconds. To paralyze it again, you might need, say, 15 or 20, and it won't stay paralyzed nearly as long, because it's slowly gaining immunity.
It stands to reason this is no different than "gaining levels," in which your characters not only get better performing certain motions as a result of their experience, but a warrior might gain muscles from getting a workout. Similarly, it would make sense that your character would develop a thicker skin in the ego department, too, over time.
But if you want another eample of depletion, you have the "Humanity" meter of the Vampire the Masquerade series. Depending on your choices you can get some back, but as you loose it your character looses control of themselves.