I'm having an interesting problem. After saving Modoc, I am not able to fire any weapons! I am still able to use items in my two slots, and use unarmed, but the AP requirements for any weapon are blanked out and I can't click on the slot to use it.
This happens with any weapon, either item slot.
Any ideas?/Anybody else had this happen to them?

Are you sure your guns are loaded? Remember that Fallout is not a game where your characters automatically reload.
If that isn't your problem, then I don't know what to tell you. I've never experienced or heard of a glitch like the one you're describing.

It's actually the second time. I assumed the first time it was a glitch, and when I reloaded, my slots were fine. So, my weapon is reloaded.
Update: I made it through with my weapon working, but now Cassidy has decided that he's perpetually near death and so runs away from enemies, and he won't equip a weapon. Vic just sits still wherever he comes into the map. Not that it matters at the end game :)
I like this game, but as the bugs build up at the end it becomes a struggle just to finish! This has happened to me every time I've played f2 - eventually I just rush to the tanker to finish because of all the bugs and glitches that happen to me.

Have you used Killaps patch (can be found at No Mutants Allowed)?
That fixed most of the bugs for me.
Mind you, I never use the companions (they slow me down!), so not sure if it helps with that.

I have not - I did install the Restoration though - does that have any bug fixes or is it just adding stuff that wasn't in the game?

As far as I'm aware, the Restoration just adds in content that was missing from the release.
Killaps patch fixes bugs.
Not sure about compatibility though, and you should be warned that Killaps patch will mean that you wont be able to use your existing save games.

Well, I guess I'll just have to finish it again before going through the game yet again. Such a disappointment. ;)
Maybe I'll try a "stupid" game - I haven't done one of those yet.