waltc: If there's a choice to be made between a Windows emulator and Bootcamp running Windows 10 natively on your Mac, the later has surely got to be easier to setup and a far better performer than a Windows emulator/translator running on OS X. With Bootcamp you not only run Windows natively just as OS X runs on your Mac, you can also run D3d/DX games on your Mac without emulation--not to mention OpenGL ~4.4/5 games under Windows (whereas OS X is still @ OpenGL 3.x--last I checked with Valve.)
The only possible fly in the ointment is that Apple's not so hot with some Windows drivers, and Bootcamp Windows drivers need to come from Apple, but in many cases the Mac is so x86 bog-standard these days that you can run the manufacturer's drivers (just like you would in any Windows box.) Just thought I'd mention it...software emulation is fine for word processors and spread sheets and browsers and other non-demanding software, but you don't want to depend on it to run demanding 3d games--it would be both buggy and objectionably slow. There are a few non-demanding games, older games, that might run fine on an emulator--maybe--but since you have a choice in the matter I would think Bootcamp would be far more attractive...
wine is not an emulator (Wine (originally an acronym for "Wine Is Not an Emulator")
https://www.winehq.org/about/ ), it only translate open gl calls to directx calls, that means almost native performance.
virtualizzation is not emulation too... because when you emulate you emulate the cpu too... like when you emulato a nds you emulate an arm cpu on a x86 one. worst performance then wine but better then emulation.
bootcamp is easier but you need to keep lots of space in your internal disk (and if you have an SSD is worst), using wine you only use the space for the application + wine, using virtualization you can put the virtual machine on a external drive.
Also you need to restart your computer using bootcamp.
Also you don't need so much power to run games like fallout, and many modern games (2012-2013) got a mac version (like metal gear rising, pillars of eternity, hitman absolution etc, and many will get one soon like trine 3 and evoland 2 (I wish for the witcher 3 too since there is a mac version of the wicher 1 and 2 that use eON a tecnology that is more native then wine but not native yet XD)....
Also if you have a macbook you still need the new one to run the witcher 3 (if you are really lucky).
OSX from Mavericks use Open GL 4.1 not 3.x anymore.
there are so many errors on your message, you clearly don't use mac, or you use wrong information.
well, I can say to you that all the games I have on gog works great on my macbook, native and wineskin one, no strange bugs. also i ported many modern games, like dark souls, dragon age origins (but there is also a wineskin official port of the 2), batman arkham origins.
read this:
http://wiki.winehq.org/Debunking_Wine_Myths