Are you playing on a laptop? Perhaps it doesn't recognise your trackpad, and you had a mouse plugged in before?
'Input Device' suggests something like that...
Seriphos: Didn't want to create a new thread, but every time I try to run Fallout 1, it gives me "Failure initializing input devices". I've tried everything from re-installing the game TO deleting my ddraw.dll TO applying all the patches (including the High-res patch) TO editing my fallout.cfg and changing the "times_run" counter to 0. Nothing works.
However, the game did work the very first time I ran it (right after installing it) and it even worked after applying all the patches that are listed in the sticky on here. But I had no time to play it that night, and when I tried running it today...this happened.