I had an issue that looked & smelled just like this.
My hardware: a Dell Latitude E6440 laptop. The significant part: it has/had *only* the CPU's 'Intel HD graphics' video interface. That seems to confuse FO3 to the level of crashing reliably and near-immediately (about 1/2-cycle through the busy-'clock') when 'new game' is pressed. I had a ball editing ini files and more.. All to zero effect. I ended up doing a test-install on another laptop that does have a non-CPU video card. Same software, clean-install: FO3 worked fine out of the 'box'...
Suspecting the video card (or rather: lack thereof) as problem: I finally found (google '"fallout 3 intel hd graphics video"):
1) youtube description here: <<yt>>/watch?v=2PW6K-7mbx8 (mangled: GOG does not want me top post links..)
2) as-mentioned there: this needs a download: (Intel HD graphics bypass package) nexusmods. com/ fallout3/ mods/ 17209? (mangled) tab=files&file_id=82734 (nexmods wants an e-mail address / registration of you for the file..). The result is a zip file with a file d3d9.dll inside. This zip file also has a txt description file of how to apply it, but basically: copy the d3d9.dll into the (for-GOG) directory: c:\GOG games\Fallout 3\ If you now restart FO3, the d3d9.dll file tricks FO3 to thinking there is more than intel-hd as video: it now reports, (start-FO3, select Option) a "NVIDIA GeForce 7900 GS".
3) Re-set your graphics resolution (not sure this is needed, but that's what I did..).
4) press PLAY..
I do not know if that has taken all the evil from the world, but: at least my FO3 actual game now starts :-) I did a test-run of the very first part of the game, at fullscreen, native resolution, and found the HD graphics not at all bad-looking.
Post edited January 06, 2020 by PrFaasse