ironwoman: Same problem here. Windows 7 64-bit.
Please don't recommend compatibility mode, already tried it.
Also tried instaliing unofficial patch, alt+tabing and screen resolution trick.
EDIT: Found a solution on Interplay forum.
You have to modify ddraw.ini in your F2 directory. Under [Graphics] just change Mode=0 to Mode=4.
That's it.
markmoore1996: i tried this and it gave me the message that i needed directX but i don't essentially want to get that, any suggestions?
There are 2 ways that can possibly help, which that don't require installing anything new.
1) Alt+Tab out of game and then return.
2) Have opened screen resolution window before you start the game. In windows 7 you right click on desktop and choose "Screen resolution"
Maybe they sound a bit strange, but I can confirm that they work in some cases.
Didn't help me for Fallout 2, but by using these tricks I solved the same problem that occured in another game - Sanitarium.