This game is a real gem. An excellent intro paves the way to some incredibly nonlinear gameplay, filled with practical humour and over the top violence. I would call it the Grand Theft Auto of RPGS. You've got drug abuse, sex, mass destruction, the works. You have plenty of weapons to choose from, deep character customization (albeit a few redundant abilities), mercenaries to hire (including a dog!), and a rich world to explore.
The levelling system is great, there is no grinding. You just survive, and you gain experience. It's a great change from traditional RPGS.
The interface certainly has a learning curve, but it's quite logical and makes sense after one is accustomed to it. The game can be long or short, depending on how you like it (don't let that 150 Water Chip post-it fool you). Many criticize the graphics, but the art direction and attention to detail overrule any such nitpicking. Sounds are done right, adding much to the atmosphere. I felt the lack of footsteps and other ambience a little disorienting, though.
In conclusion, this game is great from start to finish, and is worth it to all gamers, even if one isn't an RPG fan.
And thanks to this site for providing me the opportunity to finally play this game!