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poobum653: I am still having issues after following all the troubleshooting we have documented so far.

Fallout 4 GOTY fresh install via GOG mod installed following the instructions Installed the buffout 4 mod as well.
Dropped all settings from ultra to high, disabled motion blur, disabled wep debris,

Specs:
3080
ryzen 9 3900xt
32GB of DDR4
PCIE Gen 4 M2.

No matter what I do game seams to hard crash my whole PC needing a reboot each time, happens about every 10-15 mins of gameplay only started doing that once I got out of the train have noticed it tends to occur more when loading through doors.

Anyone got any ideas ?
Same here. I uninstalled everything per instructions, reinstalled on SSD, launch "f4se_launcher.exe" from desktop instead of GOG, changed launcher to "run as admin" and played for about 1/2 hour before it crashed to a black screen. Had to restart PC since I couldn't alt/tab to get out of the black screen. I'll just wait for another update to see if they fix the instability.