The door to the room where the Syndicate Scout is inside Dom's Cafe is 'Inaccessible'. I don't have a choice of picking the lock either. I've reloaded from a prior save and ran through the mission only to get the same result.

Background. I am at level 18 and have not done the Vagabonds quests until now. I don't know if that makes a difference.

I have only seen that door be inaccessible if I enter the building before that quest (or well after), though there is a door right near the entrance of the building (with a symbol on the door indicating it leads to the men's restroom) that remains inaccessible - I should probably double-check that you're not talking about that one.

As a workaround, you should be able to select the door with the console open and type [code]disable[/code]
You might see some blank white background, but once you go through the open doorway, the room (and hopefully the scout) will be there.

you can always use tcl command (toggle collision) to fly through walls if everything else fails

That is what I did to progress through the mission. I may have entered the building before while exploring. The door is to the small room where the Scout is located, not the men's room.

Ironically, despite having the quest marker, I had trouble finding the building itself (was circling around it, shooting the rad horses, provoking a rabid farmer, getting killed, reloading, and circling a bit longer before finally finding the well marked building for unknown reasons)
But entering it was no problem.

What bugs me, that I first let the scout go, but after she had ignorant remarks on how stupid I am, I shot her in the back. Quest got completed, but I am not sure if she should have been killed or not.