Not sure what is going on. When I try to save the game or it auto save steh game locks up and crashes. I had no problems with it while on the first island and had no problems with it prior to going to work today.
Edit--no idea what fixed this, or what cuased ti to happen in the first place, but restarting the comp cleared it up.

I have similar problems:
- Saving at the wrong time, such as during the theme music when a super-agent
lands on your island, can not only cause the game to crash but corrupt that
save. Use multiple files to save.
( taken from: http://www.n1nj4.com/EvilPlanet/TheGame/evilgenius.txt )
Only when autosaving though...