I play German and it is also my native language, there are some answers that imply a question but they would still make sense most of the time. The dialogues are some of the best and sometimes hilarious or frightening I have ever seen in a game.
There may have been one or two odd answers, not many, though.
IMHO, there are often two or more ways to continue, it is not like "do you want to know more blabla?", it is like "I rather say this to get more options" or "I say this which implies the answer and gets to the end more quickly".
It enables you to go shortcuts, but may not give you options you would have had if you did it different.
And there are no icons that indicate what something means you say. Did you ever play Mass Effect -.- You say "I love you!" and it shows an aggro symbol, now that is confusing in a game.
Like those Berserkers... I sold "Schimmeliges Brot" to, they were so grateful, I think this was some really good negotiating :D
Mad Bob gives me the creeps, Rat is such an a... (brilliant).
It really helps to not talk to every NPC immediately and just fill up your questlog, I had it with a guy near "Abessa" who wanted to join the Outlaws, I came back ~20h later and he just continued the dialogue where I left off, asking for supplies. I hit him and send him to work at that heart for the Berserkers and the "new recruit" quest or something ended without warning.