AdmiralBarrett: From what I remember, I did do well without one. I am replaying Strahd's Possession and I won't try again until I deal with Strahd and import my party. I DO remember that starting with a Cleric made the first stages much easier than they could be with a fresh party or the default quick start characters.
stryx: Are you talking about Strahd's Possession? There you would want a cleric to turn the golems, that the game throws at you. Without one you're in for a world of pain. Also healing and negative plane protection. A cleric is probably the most important class in this game, considering how many undead monsters you encounter in there, and it takes a while, till you can recruit a cleric NPC. The quick start party consists of an elven fighter/mage and a dwarven fighter/cleric. Perfectly valid.
I know Strahd's Possession like the back of my hand. :) I use a single class fighter and a cleric until I can pick up Velika and Glorianna for arcane backup. Add the Dagger of Throwing, the Rod of Smiting and the Axe of Throwing you pick up later in the game and you have a total package both up close and at range. A PC cleric is pretty much mandatory. Mischa, the NPC cleric, isn't available until after one of the nastier segments in the game (the Cemetery and the Elven Tomb). Imgarde is a crutch character for the Ilvis dungeon because of the bone golems and she is gone after that dungeon. I ALWAYS have Aid and Neg. Plane Prot. active. Turning golems is kind of a crapshoot. The quick start party characters are acceptable, but I always felt that they were not as great as they could be.
In the Stone Prophet you have access to a ranger/cleric NPC right in the beginning of the game. The quick start party consists of a half-elven cleric/ranger and an elven fighter/mage. Also perfectly valid.
I am trying them out and, to be blunt, I am not that impressed with them. I will wait until after I finish Strahd's Possession again to import my fighter and cleric.