I was wondering if there was any way to remap the controls in Duke Nukem 3D so it will have a control scheme like modern first person shooter with W, A, S, and D to move, mouse to look around, space to jump ect. I'm not used to old PC FPS and there control schemes. I pretty much have the control scheme I previous mention embed in my head when playing first person shooters.

Go to the start menu, then find the gog.com folder and duke 3d folder. Inside that should be a configuration setup shortcut. Just right click that and run it as admin and it has all the settings for controls. You can then set it up just like a modern FPS, which is how I play it.
Also the default to toggle mouselook is U.

As an alternative to Ralackk's answer, you could get a port to run it in (e.g. EDuke32). When using EDuke32 you can change the keyboard mappings and mouse control options from the game's menu system.

in windows NT 6.x versions (vista and 7) DN3D must be set to run as admin for the game to read it's config files. the control setup is done in setup.exe the prog menu has a dosbox link that boots to setup then starts the game you settings will stick. a source port moves the setup commands in to the game to modernize the ui.

What is Eduke32 and by port what do you mean? The game was ported to a newer OS?

Google will show you EDuke32 in a snap.
But to put it simply, Duke Nukem 3D was created in the Build engine and is a DOS game. To get it working in Windows, GOG have bundled it with the DOSBox emulator, so that DOS is emulated in order to play the game.
The source code for the game was released some years ago and this allowed people to create new engines to run the game, such as EDuke32.
The advantage of EDuke32 is that it is written for Windows, it does not work in DOS, so runs natively on modern Windows. Also, it allows you to use high resolution packs and 3D models, higher screen resolutions to run the game in, polymer lighting, widescreen, and more.