Won't launch out of Gog or the folder, nor as admin. Checked Steam seems others have the issue too, any fix for this? Is the game still supported?

I confirm that I can play the game from a different folder than the default one. Of note that I don't use Galaxy and I'm on Windows 7.

The game crashes when I try to use ASUS GPU Tweak III's overlay...

Are you trying to load overlays?

I used GOG Galaxy to install the game, but I tried loading the main executable; it worked.

Did you install the game using the standalone installer, or the launcher?

Hm okay this got me further into the mystery at least.

I'm getting a 'application was unable to start correctly 0xc00000018, click 'ok' to close the application.

Looks like a memory error. I tried rebooting, running it with gog galaxy off, uninstalling/reinstalling to different drives, shutting overlay and sync off, no bueno. I know Unity had a huge problem with Citrix but I fixed that and I haven't had a problem for like a year... and can't find if this's a 'unity' game or not.

running as admin, I get no error at all. running in win8 compat mode, it acts like it wants to load for a sec, but nothing pops up. virus scanner off didn't produce different results either.

Very confusing. I really don't want to uninstall/reinstall citrix again, got all my other games working. :(

update, removed citrix, still won't run. so running out of things to try.

update, removed avast, that wasn't it either.

It uses the Godot engine.

thanks yes, I found that out, and not sure if the Godot engine needs anything special to run? My wife's PC ran it just fine, mine won't. Any ideas? I uninstalled antivirus and citrix, tried running it with galaxy on and off, and with admin, and compat, totally stuck, very confused.

also tried updating direct x, and c++ visual studio, wasn't either of those either.

also tried updating my drivers, and tried shutting off overlay in adrenalin also, no go.

I encountered the same problem, where the Godot engine crashes upon startup. After trying a number of things, I was finally able to determine the problem was the lack of the Visual C Runtime v1.40 redistributables (dlls).

So I downloaded this 64-bit package from microsoft's website and installed it, then voila' Dome Keeper works!

Unfortunately I cannot post the link directly, but just search for "vc_redist.x64.exe" with google (or whatever) and look for the learn.microsoft.com link that contains "windows/latest-supported-vc-redist" in the address.

Hope this helps

sadly it wasn't the redist files, I thought it would be that too, that's generally the problem, either that or citrix is screwing it up, or antivirus, but I'm really at a loss on this one. wife's PC run's it fine. just got a new laptop so going to try that, maybe this'll be an exclusive laptop game for me something, idk.

it's got to be that it's running on a weirdass obscure engine that's conflicting with who-knows-what. this's win10 machine also so it can't be a memory thing, can it?

Godot is not a "weirdass obscure engine". I have no issues running games made with Godot on several machines, other games also would have issues if you are missing prerequisites.
Do you have the specific version of vcredist tri4orce mentioned? You need to have specific versions for some games to run, although it would be good practise to package this version. I have like 10 versions installed (32 and 64 Bit)...