Stuff: You might try a registry cleaner, I use
CCleaner (the slim build at the bottom of the list).
Alt-Tab out of the game when it hangs and make sure your firewall is not blocking the game. My firewall was throwing up confirmation dialogs behind the start screen that DD was not allowing to show. Alt-tabbing out, I could see them. (I use Comodo but others may do the same)
Might disconnect from the internet, disable both your AV and Firewall since either could be blocking the game. If it runs, enable one at a time to see which is blocking the game. Enable both prior to connecting to the internet.
I would start working my way thru the compatibility modes, change, try the game, change, etc.
Yeah, it's a great game, on my second play thru . . . =)
Edit: you might also try starting the game at different screen resolutions using the ConfigTool.exe which is located in the DD directroy. See attached image.
Depending on the res you are running, you may need to set it manually in the config.div which is also located in the DD directory. Use Notepad to open the file and enter your screen res if it is not a standard resolution found in the ConfigTool.exe.
Anything over 1280 x 1024 was just too small for me . . . =)
If you made a system restore prior to the first install, you could revert to that state as well.
Unfortunately the registry clean didn't work.
I hadn't made a system restore but I luckily had one from a recent windows update. After completing the system restore I was able to reinstall and play the game! Thank you Thank you Thank you for spending this time with me today! I wish I could buy you a coffee (or beverage of your choice). If it isn't too much trouble I wanted to ask about the reason I think it went glitchy in the first place: for some reason I'm unable to create hot keys. Can you hotkey straight from your inventory or only other screens? (I know this doesn't exactly belong here, as the real problem is solved). Thank you again!
Also thank you for the heads up about the config file. I don't like it wihen the resolution is too high. As it was the keys in the game were about 3 pixels across. XD
Edit: Answered my own question. Have to make hotkeys from the different tabs.. skills, potions, etc. :)