Yep, definitely seems that way.
Here I am playing this great game (DD - GOG version) at about 3AM, when I get a CTD while attempting to quickload. No problem...I'll just load the earlier save. Nope...another CTD. Mind you, both quicksaves are a little over a minute apart, and in nearly the same spot, but really? Both saves went and shat their pants?

That's a Level 17 Survivor, and oh say, 20-25 hours... GONE!...GONE!!! I was really enjoying Divine Divinity, but I think I'm done with it. Just reaching the point where my character was really starting to kick some ass and not having to go teleporting away all the time, too. Wasn't an easy journey.

Anyone have any recovery suggestions? Is it even possible? I tried resetting the settings, loading/quickloading the quicksaves while playing a new game, re-installing...no go.

Thanks

No recovery suggestions other than restore your system, using MS's system restore (NOT THE MANUFACTURES SYSTEM RESTORE), to a point prior to the corruption. Sorry to hear this has happened to you, I had the same early on in DD when using quick save. It only seems to occur on some systems and usually just with quick save.

I stopped using the quick save feature and had no other save corruptions. I just use the "S" key to save. (See the "Key map" for all the DD keys)

If you are using Vista / Win 7 and you have not done so already, right click the game short cut, click Properties, click the Compatibility tab, check mark "Run this program as an administrator" I also suggest you check "Disable visual themes" and "Disable desktop composition". (it's just for the game). UAC seems to interfere with saves (disk writes) on some systems.

For Vista / Win 7 I suggest you install in a directory outside of Program files, make sure you install by right clicking the setup.exe, click "Run as an Administrator" and do the short cut thing above. Not doing the above can cause a partial install which can block some disk writes.

Edit: You might also make the div.exe a trusted program in your firewall program as some firewalls can interfere with saves if this is not done. (Comodo in particular) Often the firewall is th culprit if you get the save corruptions on XP.

Guess I should've mentioned I'm on XP.
I never received the firewall warning, but have in the past for many games. Sucks if that's what did it. Thanks for your help and the quick response, Stuff.

You're welcome, sorry I had no real solution for you. I was on XP when my save corruptions happened. Comodo was throwing several "Allow this" dialogs behind the game screen. I didn't see them until I ALT - Tabbed out of the game. I would ok one but another would pop up. After making the div.exe a trusted program, the prompts stopped. I used the S key after that just to be sure . . . =)